AP2S1

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1gene.[5][6][7]

AP2S1
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE

Identifiers
Aliases AP2S1, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDs OMIM: 602242MGI: 2141861HomoloGene: 3001GeneCards: AP2S1
Gene location (Human)
Chr. Chromosome 19 (human)[1]

Band 19q13.32 Start 46,838,136 bp[1]
End 46,850,846 bp[1]
Gene location (Mouse)
Chr. Chromosome 7 (mouse)[2]

Band 7|7 A2 Start 16,738,410 bp[2]
End 16,749,294 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • smooth muscle tissue
  • amygdala
  • dorsolateral prefrontal cortex
More reference expression data
BioGPS

More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

1175

232910

Ensembl

ENSG00000042753

ENSMUSG00000008036

UniProt

P53680

P62743

RefSeq (mRNA)

NM_001301076
NM_001301078
NM_001301081
NM_004069
NM_021575

NM_198613

RefSeq (protein)

NP_001288005
NP_001288007
NP_001288010
NP_004060
NP_067586

NP_941015

Location (UCSC) Chr 19: 46.84 – 46.85 Mb Chr 7: 16.74 – 16.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.[7]

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  1. GRCh38: Ensembl release 89: ENSG00000042753Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000008036Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). “Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3”. Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.
  6. Holzmann K, Poltl A, Sauermann G (Nov 1998). “A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17”. Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
  7. “Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit”.

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