Histone H4 is a protein that, in humans, is encoded by the HIST1H4Igene.[5][6][7][8]

Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Aliases H4C9, H4/m, H4FM, H4M, histone cluster 1, H4i, histone cluster 1 H4 family member i, H4 clustered histone 9, HIST1H4I, H4C5, H4C4, H4C12, H4-16, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2
External IDs OMIM: 602833MGI: 2448427HomoloGene: 134482GeneCards: H4C9
Gene location (Human)
Chr. Chromosome 6 (human)[1]

Band 6p22.1 Start 27,138,588 bp[1]
End 27,139,881 bp[1]
Gene location (Mouse)
Chr. Chromosome 13 (mouse)[2]

Band 13|13 A3.1 Start 23,531,050 bp[2]
End 23,531,519 bp[2]
RNA expression pattern
Top expressed in
  • stomach
  • blood
  • colon
  • lung
  • Right lobe of liver
  • lymph node
  • kidney
  • heart
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 27.14 – 27.14 Mb Chr 13: 23.53 – 23.53 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[8]

. . . HIST1H4I . . .

  1. GRCh38: Ensembl release 89: ENSG00000276180Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060981Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Akasaka T, Miura I, Takahashi N, Akasaka H, Yonetani N, Ohno H, Fukuhara S, Okuma M (Jan 1997). “A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin’s lymphoma results in replacement of the 5′ regulatory region of BCL6 with a novel H4 histone gene”. Cancer Res. 57 (1): 7–12. PMID 8988030.
  6. Albig W, Doenecke D (Feb 1998). “The human histone gene cluster at the D6S105 locus”. Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  7. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). “The human and mouse replication-dependent histone genes”. Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. “Entrez Gene: HIST1H4I histone cluster 1, H4i”.

. . . HIST1H4I . . .

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. . . HIST1H4I . . .